Download DevCon from Microsoft.

Find the instance ID of your CD-ROM drive:

devcon find *CDROM*

Now, use this instance ID (everything before the : sign) to disable the drive:

devcon disable "@IDE\CDROMMATSHITA_UJDA755ZDVD/CDRW_______________1.2
0____\5&3CCF215&0&0.0.0"
IDE\CDROMMATSHITA_UJDA755ZDVD/CDRW_______________1.20____\5&3CCF215&0&0.0.0: Disabled
1 device(s) disabled.

devcon enable "@IDE\CDROMMATSHITA_UJDA755ZDVD/CDRW_______________1.20
____\5&3CCF215&0&0.0.0"
IDE\CDROMMATSHITA_UJDA755ZDVD/CDRW_______________1.20____\5&3CCF215&0&0.0.0: Enabled
1 device(s) enabled.

Do not forget to add the @ sign before the device ID. Haven’t seen any mention of this in help (found it in examples).
And unfortunately if you don’t put it you will not get any error message - it will just not do anything, as if you didn’t have enough permission.
You will also need to enclose the device ID in quotes.

More examples here.